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Aldol Addition/Condensation
Kerolos_4875
#1 Posted : Thursday, July 23, 2020 7:02:27 AM
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Hi,

Question about the terminology: does the enolate ion or the carbanion do the nucleophilic attack on the next aldehyde/ketone? is there a difference even or are they synonyms? Also, it is the nucleophilic carbon doing the attack, not the oxygen, right?

Thank you guys for all your support so far!
INSTR_Molly_59
#2 Posted : Thursday, July 23, 2020 7:35:25 PM
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For aldol condensation, base-catalyzed removal of the alpha hydrogen results in the formation of a carbanion (negative charge on the carbon) which attacks the carbon of the carbonyl from an aldehyde/ketone. The enolate (negative charge on oxygen) is distinct from the carbanion, but is the resonance structure of the alpha carbanion.

I hope that helped! If you have any more questions, feel free to ask away! :)
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