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pyruvate dehydrogenase complex
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Jingxuan_5036
#1 Posted : Saturday, July 04, 2020 6:47:09 PM
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Does the PDC complex require oxygen/can it function anaerobically? Also, why is the PDC stimulated by high levels of AMP and not ATP?
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INSTR_Rheann_72
#2 Posted : Monday, July 06, 2020 2:44:53 PM
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Although PDC does not directly require O2 the purpose of it is to link glycolysis to the citric acid cycle which only occurs in a an aerobic state. The purpose of the PDC is to create more ATP (via the citric acid cycle) and so when there is a lot of ATP it will be inhibited (we don't need to make more energy) and when there is a lot of AMP (not a lot of ATP) it will be activated as we need more energy. Hope this helps!
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