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Nicole_5521
#1 Posted : Wednesday, July 28, 2021 5:13:06 AM
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Hello,

For Q43, I'm confused about the reasoning for the answers. Is it because a stop codon is likely near the carboxy end? And so, if a stop codon is unaffected in the mutation, the mutation likely is nearer the carboxy end since there's less of a chance for something major changing?

Thank you!!
INSTR_Shinthujah_131
#2 Posted : Friday, August 06, 2021 11:03:45 PM
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Hi Nicole,

The way I understood it, when you add a nucleotide into the open reading frame (ORF), it will cause a frameshift mutation downstream to where the nucleotide was added. So the amino-terminal sequence (at the start) wouldn't be changed, but the carboxy-terminal (near the end) more probably will. The stop codon comes after the ORF, which was unchanged as the question said, so its probably something before it (carboxy end).

Hope this helps!
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