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Emma_5484
#1 Posted : Friday, July 24, 2020 9:33:45 PM
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Hi there,

For gluconeogenesis it says that it requires 3 carbon molecules (glycerol, lactate, AA, ect.) however, it intersects the glycolysis pathway at G6P which is a 6 carbon molecule. I was just wondering why/how this happens.

Thanks!
Emma
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INSTR_Shinthujah_68
#2 Posted : Saturday, July 25, 2020 12:02:41 AM
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Hi Emma,

The gluconeogenesis pathway typically starts in the conversion of pyruvate to oxaloacetate, then oxaloacetate to PEP. And then continues in the reverse of the glycolysis pathway, with different enzymes at the steps, up until glucose.

There are other precursors (like lactate, certain amino acids, and glycerol) that can feed into the gluconeogenesis pathway at different points. For instance, lactate get converted to pyruvate and then joins the pathway (this is beyond your scope for the MCAT).

The following video goes into more detail than you need for the MCAT, but it might help solidify your understanding: https://www.youtube.com/watch?v=2dmr3-kJu_M

I hope this helps!
-Shin
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