Welcome Guest Search | Active Topics |

Tag as favorite
Cell-mediated immunity
Options
Previous Topic Next Topic
Mar_4935
#1 Posted : Sunday, July 26, 2020 11:05:17 PM
Rank: Newbie

Groups: Registered
Joined: 4/10/2020
Posts: 4

Thanks: 0 times
Was thanked: 0 time(s) in 0 post(s)
Hello!

I had a question about the exogenous pathway (MHCII). Could you tell me if this is correct?

1.the pathogen is engulfed by a phagocytic cell and degraded in the lysosome
2.the MHCII associated with the antigen
3.exocytosis of the complex to plasma membrane
4.Helper T cell CD4 binds to MHCII-antigen

And also, after CD4 binds, is perforin released (as it happens in the endogenous pathway) to lyse the cell?

Thank you so much!
Mar
Back to top
Report?
INSTR_Katerina_102
#2 Posted : Tuesday, July 28, 2020 7:16:06 AM
Rank: Advanced Member

Groups: Registered
Joined: 6/24/2019
Posts: 250

Thanks: 0 times
Was thanked: 0 time(s) in 0 post(s)
Hi Mar,

I had a question about the exogenous pathway (MHCII). Could you tell me if this is correct?

1.the pathogen is engulfed by a phagocytic cell and degraded in the lysosome
2.the MHCII associated with the antigen
3.exocytosis of the complex to plasma membrane
4.Helper T cell CD4 binds to MHCII-antigen


This looks about right. There is a diagram on page 167 of the BioBiochem CC that should halp with this.


And also, after CD4 binds, is perforin released (as it happens in the endogenous pathway) to lyse the cell?


This seems reasonable as you would want to lyse the cell containing the invader. I am not 100% sure on this, but I cannot find any literature saying that this is not the case.
Back to top
Report?
Users browsing this topic
Guest
Tag as favorite
You cannot post new topics in this forum.
You cannot reply to topics in this forum.
You cannot delete your posts in this forum.
You cannot edit your posts in this forum.
You cannot create polls in this forum.
You cannot vote in polls in this forum.

Clean Slate theme by Jaben Cargman (Tiny Gecko)
Powered by YAF | YAF © 2003-2009, Yet Another Forum.NET
This page was generated in 0.098 seconds.