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Amino Acids
Natasha_4902
#1 Posted : Thursday, July 30, 2020 2:36:09 AM
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Hi,

How are proteins made with amino acids that differ from the common 20 amino acids? Are there more codons than the 64 in the codon chart?

Thank you
INSTR_Katerina_102
#2 Posted : Thursday, July 30, 2020 7:44:30 AM
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Hi Natasha,

Great question!

There are not more codons than those in the chart.

Non canonical amino acids can be made in two ways in the body:

1. Non ribosomal peptide synthetases (enzymes that perform synthesis of proteins like ribosomes, but don't scan an mRNA to get the order of amino acids).

2. Post-translational modification by other enzymes, oxidizing and reducing select canonical amino acids to transform them into the desired non-canonical amino acids.

I hope this helps!

Katt
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