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Moiz_6047
#1 Posted : Friday, May 14, 2021 12:16:45 AM
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Hi!

Is glycogen a polymer of glucose? Can glycogen be broken down via hydrolysis into glucose, or adding a phosphate group instead?
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Youssef_6546
#2 Posted : Friday, May 14, 2021 12:35:31 AM
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Hi Moiz,

Yes, glycogen is a polymer of glucose. No, during glycogen breakdown, water is not used to break apart glycogen. Instead, an inorganic phosphate is used to perform phosphorolysis via a enzyme called glycogen phosphorylase. We then get glucose-1-phosphate subunits after phosphorolysis (not glucose). These subunits are then converted back to glucose-6-phosphate then glucose.

Hope these help!
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INSTR_Sydney_132
#3 Posted : Thursday, May 20, 2021 5:47:14 PM
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Yes - glycogen is a polymer of glucose.

When the amount of glucose reduces in the blood and the body needs glucose, the stored glucose in the liver and muscle is broken down to form glucose. The process of liberating glucose from glycogen is known as glycogenolysis. This is carried out by the enzyme glycogen phosphorylase. Glycogen phosphorylase catalyzes the rate-limiting step in glycogenolysis in animals by releasing glucose-1-phosphate from the terminal alpha-1,4-glycosidic bond. Thus - the breakdown of glycogen requires a phosphorylation step, rather than undergoing hydrolysis.

Hope this helps!
- Sydney
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