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Inbreeding
Vaishaalie_6729
#1 Posted : Thursday, May 20, 2021 7:55:14 PM
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In Lecture 1 of the Biology 2: Systems Study Guide, it mentions how inbreeding increases homozygosity but does not change allele frequency. I would love any clarification on how the allele frequency is not effected by the increase in homozygosity.
Youssef_6546
#2 Posted : Thursday, May 20, 2021 9:19:23 PM
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Hi Vaishaalie,

Recall the Hardy-Weinberg equilibrium equation: p^2 + 2pq + q^2 = 1, as this would help us determine if a population has undergone evolution or not. Based on my understanding, inbreeding increases the number of homozygous individuals in the population, which is an increase in genotype frequency (i.e. p^2, 2pq, and q^2) and not allele frequency (p and q). Usually the only way to change a population’s allele frequency is through a change in the organism’s alleles found on their chromosome (i.e. via a mutation, gene flow, or genetic drift). With inbreeding, there’s an increase in the proportion of homozygotes relative to heterozygotes, which doesn’t necessarily mean a change in the chromosome occurred. However, due to natural selection, the inbred population will eventually experience a allele frequency.

Hope these help!
Vaishaalie_6729
#3 Posted : Friday, May 21, 2021 3:31:16 AM
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Hey Youssef!

Yes that makes sense! Thank you very much. If it's alright with you, could you let me know if I'm on the right track?

Inbreeding (according to the Hardy-Weinberg equilibrium equation) will cause an increase in p^2 and q^2 (homozygotes) and a decrease in 2pq (heterozygotes). In turn, the allele frequency of one allele would not increase/decrease significantly over the other. The only change that would result from inbreeding would be a significant increase in the ratio of homozygotes to heterozygotes (allele frequency would remain unaffected).

I am hoping this is correct. Thank you for your time!
Youssef_6546
#4 Posted : Friday, May 21, 2021 4:33:19 AM
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You're right! :D
INSTR_Kennedy_135
#5 Posted : Tuesday, July 20, 2021 8:40:06 PM
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Glad you guys were able to figure it out :) Good work team!
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