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Lydia_5054
#1 Posted : Wednesday, July 14, 2021 3:20:20 PM
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Hi

I was just wondering how we go about this question with the knowledge of retroviruses. If we have our mRNA, then to find the original viral genome, wouldnt we just get the cDNA of that strand? im just confused because all i know is that it would be the reverse central dogma so from mrna to dna so i just don't get whats happening here.
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INSTR_Kennedy_135
#2 Posted : Tuesday, July 20, 2021 11:36:41 PM
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Yep you are on the right track!

With a retrovirus you can reverse transcription, so you would go from mRNA to (c)DNA. The MRNA will be digested by reverse transcriptase, and a complimentary strand to the mRNA will be made= cDNA. Then DNA polymerase will help the cDNA double-stranded. The cDNA is the DNA without any introns as it come from the mRNA that already had them removed.

It still follows the central dogma, just with the adjustment of no introns so you refer to it as cDNA.
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