Hello,

I had a question from the AAMC section bank .

I’m just confused on the reasoning behind this answer,

“ A single point mutation in a gene results in a non functional protein . Individuals heterozygous for this mutation were identified using souther blot. Which pair of wild type and mutant alters most likely contains the mutation ?

The correct answer is :

WT: 5’TAGTCGAAGCTTAGGCATCT-3
M: 5’TAGTCDATGCTTAGGCATCT-3

MUTANT (M)

THANK YOU!